Quickly find freely available drug and population models in our PBPK model repository.
The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.>
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Disease: Malaria
Drug Class: Antimalarials
Date Updated: March 2022
Related Files: Primaquine (parent)
Absorption Model |
N/A |
Volume of Distribution |
Full PBPK (Method 2) |
Route of Elimination |
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Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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Brand Name(s) include: Coartem
Disease: Malaria
Drug Class: Antimalarials
Date Updated: June 2021
Absorption Model |
First-Order |
Volume of Distribution |
Note: A Kp scalar (0.5) was used in the model along with optimized partitioning into adipose tissue (Kp,adipose = 0.5) to recover the clinical observed data. |
Route of Elimination |
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Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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The V21 RES-Dasabuvir model has been developed as a substrate of CYP2C8 and CYP3A4. Compound file and performance summary are available.
Simcyp developed Docetaxel compound file. Compound summary document included. This was developed as a research file and its current status and limitations are outlined in summary document.
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