Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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Found 147 Matches

Adefovir_V15R1_USFDA_20170810

Model Files Publication

http://onlinelibrary.wiley.com/doi/10.1002/cpt.750/full Adefovir compound in healthy volunteers. Hsueh et al evaluating the effect of renal impairment on PK of OAT substrates. 30/07/2019: The Adefovir PBPK model was submitted with the setting as Hepatocyte Clearance input in the WOMC option. To allow DDI simulations the file should be set up in the Enzyme Kinetics option by moving the Hepatocyte clearance value into the Additional Clearance (Liver) subtab under the Enzyme Kinetics section.

Search Score: 1

Cetirizine_V14R1_AstraZeneca_20200327

Model Files Publication

Cetirizine for pediatric predictions.

Search Score: 1

Dabigatran&DabigatranEtexilate_V17R1_UniversityOfTsukuba_20190204

Model Files Publication

Dabigatran etexilate and dabigatran compound files. Assessment of potential DDIs with P-gp inhibitors in renal impairment populations. https://www.ncbi.nlm.nih.gov/pubmed/30659778 https://doi.org/10.1002/psp4.12382

Search Score: 1

Dabrafenib_V15R1_FlindersUniversity_20180331

Model Files Publication

Dabrafenib compound file

Search Score: 1

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Adefovir_V15R1_USFDA_20170810

Cetirizine_V14R1_AstraZeneca_20200327

Dabigatran&DabigatranEtexilate_V17R1_UniversityOfTsukuba_20190204

Dabrafenib_V15R1_FlindersUniversity_20180331

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