Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 88 Matches

V19 Res Boosted Atazanavir April 2021
V19 Res Boosted Atazanavir April 2021
Benzylpenicillin_RES_V20R1_Simcyp_20210512

The RES-Benzylpenicillin file was primarily developed as a substrate of renal OAT3 transport. This document provides: 1. Examples of model performance 2. A summary of the key pharmacokinetic features of benzylpenicillin considered within the model.

Bergamottin_V19R1_AstraZeneca_20210423
CYP inhibitor found in grapefruit juice. AstraZeneca file.
Cidofovir_V12R1_FDA_20150709
Table 1 of main text, further discussion in supplemental file. Clarification: the value of intrinsic CL for hepatic elimination (0.41) is for undefined human liver microsomes according to retrograde calculation, with a unit of uL/min/mg. The operating hepatic CLint is driven by S9, which has a value of 0.13, obtained from sensitivity analysis to match HLM value above. This clarification will be informed to the journal.

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