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Brand Name(s) include: Qualaquin
Disease: Malaria
Drug Class: Antimalarials
Date Updated: 2021
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Absorption Model |
First-Order |
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Volume of Distribution |
Minimal PBPK (Method 1) |
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Route of Elimination |
CYP3A4 (fm = 0.50); renal clearance (fe = 0.1) |
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Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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This model is a Crohn's disease (CD) population model for adult patients, created in Simcyp version 19. Alteration of GIT parameters and other physiological parameters like albumin level incorporated based on literature available data of inactive state of CD. The demographic and formulation information are based on the published in vivo pharmacokinetics data of midazolam and budesonide in CD patients. The model details and results are published in 2022 DOI: 10.1007/s40262-022-01169-4
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15 |