Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

|<

<

1

2

3

4

5

6

7

8

9

10

11

12

13

14

>

>|

Found 110 Matches

Lamivudine_V18R1_Simcyp_20200212
FO, mainly renally excreted. Has been used with HV, pregnancy population and elderly population.
Tenofovir_V18R1_Simcyp_20200212
Tenofovir dispoproxil fumarate: the dose was calculated to correct for the prodrug. FO, full PBPK model with method 2 and KP scalar. Mainly renally excreted (renal clearance input, not mechanistic).
Tizanidine_V18R1_LongIslandUniversity_20210119
This is compound file for tizanidine, a CYP1A2 substrate. The input values for the Tizanidine PBPK model are listed in table 1 of the publication. The file uses a User fugut of 1E-06. A solid formulation is used with the segregated transit time model activated and a predicted aqueous phase intrinsic solubility.
Pyrimethamine

Brand Name(s) include: Daraprim

Disease: Malaria

Drug Class: Antimalarials

Date Updated: November 2021

Model at-a-glance

  Absorption Model

  • First-Order

  Volume of Distribution 

  • Full PBPK (Method 2) 

Note: Kp scalar used

  Route of Elimination

  • Non-specific hepatic metabolism (metabolizing enzymes not known)

  Perpetrator DDI

  • OCT1 and OCT2 inhibitor

  Validation

  • Three clinical studies were available for model verification.  100% of simulated Cmax and AUC were within 1.5-fold of observed and hence the model performance was deemed acceptable.

  Limitations

  • The current model does not describe enzyme specific metabolism of pyrimethamine as there are no data for specific routes of metabolism.​

The current model does not mechanistically describe the absorption of pyrimethamine as the ADAM model over-predicts the extent of absorption. Although pyrimethamine is described as well absorbed in some literature, further analysis of the IV and PO data did not support this. 

  Updates in V19

  • Updated in vitro­ data
    • fup: 0.085 -> 0.095

 

|<

<

1

2

3

4

5

6

7

8

9

10

11

12

13

14

>

>|