Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 142 Matches

Fluoxetine&Norfluoxetine_V12R2_USFDA_20160511
Optimized, personal communication with Dr. Snoeys
Iloperidone_V12R2_USFDA_20160510
Note/correction: predicted B/P should be 0.70, predicted Fa should be 0.84
Sotalol_V14R1_ AstraZeneca_20200327
Sotalol for pediatric predictions.
Rosuvastatin_V17R1_ASTAR_20190724
The submitted compound file for Rosuvastatin uses ADAM, Full-PBPK method 2, enzyme kinetics for metabolism and transporter kinetics for the permeability limited liver model and MechKim model. Tissue : Plasma partition coefficients have been modified to include data obtained from rat distribution studies. It has been used together with the unmodified Sim-Healthy Volunteer library file. https://www.ncbi.nlm.nih.gov/pubmed/31079160

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