Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 102 Matches

Dabigatran&DabigatranEtexilate_V17R1_UniversityOfTsukuba_20190204

Model Files Publication

Dabigatran etexilate and dabigatran compound files. Assessment of potential DDIs with P-gp inhibitors in renal impairment populations. https://www.ncbi.nlm.nih.gov/pubmed/30659778 https://doi.org/10.1002/psp4.12382

Search Score: 1

Lamotrigine_V17R1_HussonUniversity_20210628

Model Files Publication

https://pubmed.ncbi.nlm.nih.gov/30460522/ Lamotrigine IR and XR formulations in adults and in children aged between 4 and 17 years. 1) The file is set as FO file (IR formulation), the ADAM model can be activated and the corresponding models, like the segregated transit time model are then available to simulate the XR formulation. 2) The model is using absolute scaling for UGT1A3 and UGT1A4. For V21 the absolute abundance data for UGT1A3 were updated and hence the corresponding ISEF may require adjustment if the file is used in later versions.

Search Score: 1

Curcumin_Japanese_V19R1_AstraZeneca_20210726

Model Files Publication

For curcumin, the Japanese population library file from the Simcyp Human Simulator was used, and a sulfotransferase clearance pathway was incorporated as published for the curcumin PBPK model (Physiologically-Based Pharmacokinetic Predictions of the Effect of Curcumin on Metabolism of Imatinib and Bosutinib: In Vitro and In Vivo Disconnect - PubMed (nih.gov)). The curcumin model used in the publication linked is also based on this earlier published model. Fugut=1 represents worst-case scenario DDI while Fugut=0.03 represents assumption that fu,gut = fu,whole blood.

Search Score: 1

V21R1_BisphenolA_JagiellonianUniversity_20230711

Model Files Publication

The dataset can be found at the following URL: https://data.mendeley.com/datasets/t7t8kbjpyg/1

Search Score: 1

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Dabigatran&DabigatranEtexilate_V17R1_UniversityOfTsukuba_20190204

Lamotrigine_V17R1_HussonUniversity_20210628

Curcumin_Japanese_V19R1_AstraZeneca_20210726

V21R1_BisphenolA_JagiellonianUniversity_20230711

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