Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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Found 62 Matches

KoreanGeneral_Population_V15R1_SeoulNationalUniversityAndHospital_20190424

Model Files Publication

General Korean population for Simcyp.

Search Score: 2

KoreanHealthy_Population_V15R1_SeoulNationalUniversityAndHospital_20190424

Model Files Publication

Healthy Korean population for Simcyp.

Search Score: 2

Pitavastatin_RES_V20R1_Simcyp_20211102

Model Files Publication

The RES-Pitavastatin file was developed as a CYP2C9, UGT1A3/2B7, OATP1B1/1B3/2B1, NTCP substrate This document provides: 1. Examples of model performance 2. A summary of the key pharmacokinetic features of pitavastatin considered within the model.

Search Score: 1

Azithromycin

Model Files Publication

Brand Name(s) include: Zithromax

Disease: Malaria

Drug Class: Marcolide Antibiotic

Date Updated: March 2021

The model at-a-glance

Absorption Model	First-Order
Volume of Distribution	Full PBPK (Method 2) Note: A Kp scalar (0.04) was used in the model
Route of Elimination	No metabolism; a biliary CLint was input based on clinical data
Perpetrator DDI	None
Validation	Two clinical studies describing single and multiple dose exposure of atovaquone were used to verify the PBPK model. 100% of studies were within 1.5-fold.
Limitations	There are some data to suggest atovaquone is an inhibitor of BCRP. This is currently not included within the model.
Updates in V19	Updated in vitrodata LogP: 5.8 -> 8.4 Caco-2 P_app > 300 x 10-6 cm/s Propranolol Papp 101 x 10-6 cm/s Optimized ka and t_lag Converted from minimal PBPK model to full PBPK model

Search Score: 1

Search the PBPK Model Repository

Searching Tips

KoreanGeneral_Population_V15R1_SeoulNationalUniversityAndHospital_20190424

KoreanHealthy_Population_V15R1_SeoulNationalUniversityAndHospital_20190424

Pitavastatin_RES_V20R1_Simcyp_20211102

Azithromycin

The model at-a-glance

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