Quickly find freely available drug and population models in our PBPK model repository.
The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.>
You can use a suffix operator (*) as the placeholder for end of a term. The query must start with at least one alphanumeric character before the suffix operator. E.g., Rifam* will get you “Rifampicin” and “Rifampin”. For more advanced searching tips click here.
Brand Name(s) include: Intelence
Disease: HIV
Drug Class: Non-nucleoside reverse transcriptase inhibitors
Date of Review: 2020
Number of Models Reviewed: 3
Number of Models added to the Repository: 1
Publication |
Moltó, J., Rajoli, R., Back, D., Valle, M., Miranda, C., Owen, A., Clotet, B., & Siccardi, M. (2017). Use of a physiologically based pharmacokinetic model to simulate drug-drug interactions between antineoplastic and antiretroviral drugs. The Journal of antimicrobial chemotherapy, 72(3), 805–811. |
Simcyp Version |
Not a Simcyp model (Matlab/Simbiology) |
Published Model Application |
Simulation of DDIs |
Absorption Model |
Compartmental absorption |
Volume of Distribution Details |
Full PBPK |
Route of Elimination |
|
Perpetrator DDI |
|
Advantages and Limitations |
|
Model Compound Files |
|
Publication |
Rajoli, R. K., Back, D. J., Rannard, S., Freel Meyers, C. L., Flexner, C., Owen, A., & Siccardi, M. (2015). Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV. Clinical pharmacokinetics, 54(6), 639–650. |
Simcyp Version |
Not a Simcyp model (Matlab/Simbiology) |
Published Model Application |
Long-acting injectable formulation assessment |
Absorption Model |
Compartmental and transit model |
Volume of Distribution Details |
Full PBPK |
Route of Elimination |
|
Perpetrator DDI |
|
Advantages and Limitations |
|
Model Compound Files |
|
Publication |
Litou, C., Turner, D. B., Holmstock, N., Ceulemans, J., Box, K. J., Kostewicz, E., Kuentz, M., Holm, R., & Dressman, J. (2020). Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 149, 105297. |
Simcyp Version |
V17 |
Published Model Application |
Prediction of Food Effect |
Absorption Model |
ADAM |
Volume of Distribution Details |
Full PBPK |
Route of Elimination |
|
Perpetrator DDI |
|
Advantages and Limitations |
|
Model Compound Files |
|
11 |