Quickly find freely available drug and population models in our PBPK model repository.
The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.>
You can use a suffix operator (*) as the placeholder for end of a term. The query must start with at least one alphanumeric character before the suffix operator. E.g., Rifam* will get you “Rifampicin” and “Rifampin”. For more advanced searching tips click here.
Brand Name: Edurant, Rekambys
Disease: HIV
Drug Class: non-nucleoside reverse transcriptase inhibitor
Version: 21
Date Updated: March 2024
Absorption Model |
First order |
Volume of Distribution Details |
Full PBPK (Method 3) |
Route of Elimination |
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Perpetrator DDI |
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Validation |
The refined model was able to recover clinically observed concentration-time profiles of rilpivirine following single and multiple dosing. Seven clinical DDI studies where rilpivirine was administered with either efavirenz, ketoconazole, rifampin, or rifabutin were used to verify the PBPK model of rilpivirine as a victim. In comparison of predicted vs. observed AUC, 85.7% of the studies were within 1.5-fold. Three clinical DDI studies where rilpivirine was administered with either sildenafil, ethinylestradiol, or midazolam were used to verify the PBPK model of rilpivirine as a perpetrator. In comparison of predicted vs. observed AUC, 100% of the studies were within 1.25-fold. |
Limitations |
The net in vivo effect of rilpivirine as either an inhibitor or an inducer of CYP3A appears to be negligible based on the available DDI studies |
Brand Name(s) include: Viread
Disease: HIV
Drug Class: Nucleoside Reverse Transcriptase Inhibitors (NRTI)
Date of Review: 2020
Number of Models Reviewed: 3
Number of Models added to the Repository: 3
Publication |
De Sousa Mendes, M., Chetty, M. Are Standard Doses of Renally-Excreted Antiretrovirals in Older Patients Appropriate: A PBPK Study Comparing Exposures in the Elderly Population With Those in Renal Impairment. Drugs R D 19, 339–350 (2019). |
Simcyp Version |
V17 |
Absorption Model |
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Volume of Distribution Details |
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Route of Elimination |
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Perpetrator DDI |
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Advantages and Limitations |
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Model Compound Files |
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Publication |
Liu S N, Desta Z, Gufford B T. Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis[J]. CPT: pharmacometrics& systems pharmacology, 2020, 9(1): 40- 47. |
Simcyp Version |
V15 |
Absorption Model |
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Volume of Distribution Details |
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Route of Elimination |
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Perpetrator DDI |
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Advantages and Limitations |
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Model Compound Files |
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Publication |
De Sousa Mendes M, Hirt D, Urien S, Valade E, Bouazza N, Foissac F, Blanche S, Treluyer JM, Benaboud S. Physiologically-based pharmacokinetic modeling of renally excreted antiretroviral drugs in pregnant women. Br J Clin Pharmacol. 2015 Nov;80(5):1031-41. |
Simcyp Version |
V13 |
Published Model Application |
Prediction of exposure in pregnancy |
Absorption Model |
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Volume of Distribution Details |
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Route of Elimination |
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Perpetrator DDI |
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Advantages and Limitations |
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Model Compound Files |
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Brand Name(s) include: Biltricide, Cysticide, Praquantel
Indication: Schistosomiasis and clonorchiasis/opisthorchiasis due to the liver flukes
Drug Class: Anthelmintic
Version: 22
Date Updated: February 2024
Absorption Model |
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Volume of Distribution Details |
Full model (method 3) |
Route of Elimination |
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Perpetrator DDI |
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Validation |
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Limitations |
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Brand Name(s) include: Basoquin, Camoquin, Flavoquin, Coarsucam
Disease: Malaria
Drug Class: Antimalarials
Date Updated: June 2021
Absorption Model |
First-Order |
Volume of Distribution |
Full PBPK (Method 2) |
Route of Elimination |
CYP2C8 = 72%; Additional HLM = 28% |
Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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6 |