Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 121 Matches

Sulfadoxine

Brand Name(s) include: Fansidar

Disease: Malaria

Drug Class: Sulfonamide

Date Updated: March 2021

The model at-a-glance

  Absorption Model

  • First-Order

  Volume of Distribution

  • Minimal PBPK (User input Vss)

  Route of Elimination

  • Renal clearance (90%); non-specific hepatic metabolism (10%)

  Perpetrator DDI

  • None

  Validation

  • Four clinical studies describing single and multiple dose exposure of sulfadoxine were used to verify the PBPK model. In comparison of predicted vs. observed AUC, 100% of the studies were within 2-fold and 75% were within 1.5-fold. 

  Limitations

  • In the absence of adequate data on the metabolism and excretion of sulfadoxine, it was assumed that 90% was cleared renally and 10% was metabolized by the liver.

  Updates in V19

  • Updated in vitro­ data
    • LogP: 4.22 -> 0.54

 

Sulfasalazine_RES_V18R1_Simcyp_20190118

Simcyp developed sulfasalazine compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

V16 Res Chloroquine Simcyp July 2017
V16 Res Chloroquine Simcyp July 2017
Sotalol_V14R1_ AstraZeneca_20200327
Sotalol for pediatric predictions.

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