Quickly find freely available drug and population models in our PBPK model repository.
The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.
To contribute published user compound and/or population files, upload your files here: Upload Model Files
http://onlinelibrary.wiley.com/doi/10.1002/cpt.750/full Ganciclovir compound file in healthy volunteers. Evaluation of the effect of renal impairment on the PK of OAT substrates. NOTE: Kp scaler in model should be 0.33, different from Table 1.
Simcyp developed sulfasalazine compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.
http://dmd.aspetjournals.org/content/47/5/493.long Maraviroc and Telaprevir/healthy volunteer. The workspace is set up as multiple dose over 10 days to account for the MBI of Telaprevir. The metabolite of Telaprevir (VRT-127394) is included in the workspace.
The V23 Interleukin-6 (IL-6) research file has been developed as a therapeutic-protein modulator, acting as a suppressor of CYP1A2, CYP2C9, CYP2C19 and CYP3A4/5. The model has been verified against clinical data across a wide spectrum of IL-6 levels and various health conditions. The model has also been utilised to evaluate the time-course and magnitude of therapeutic protein-drug interaction during cytokine storm triggered infection and T-cell engager therapies.
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