Quickly find freely available drug and population models in our PBPK model repository.
The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.>
You can use a suffix operator (*) as the placeholder for end of a term. The query must start with at least one alphanumeric character before the suffix operator. E.g., Rifam* will get you “Rifampicin” and “Rifampin”. For more advanced searching tips click here.
Brand Name(s) include: Kaletra (fixed dose combination with low dose ritonavir)
Disease: HIV
Drug Class: Protease inhibitor
Date of Review: 2020
Number of Models Reviewed: 1
Number of Models added to the Repository: 1
Publication |
Wagner et al., Physiologically-Based Pharmacokinetic Modeling for Predicting the Effect of Intrinsic and Extrinsic Factors on Darunavir or Lopinavir Exposure Co-administered with Ritonavir. J Clin Pharmacol. 2017 October ; 57(10): 1295–1304. (FDA model) |
Simcyp Version |
V13 |
Absorption Model |
First-Order |
Volume of Distribution Details |
Minimal PBPK |
Route of Elimination |
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Perpetrator DDI |
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Advantages and Limitations |
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Model Compound Files |
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Brand Name(s) include: Coartem (artemether, lumefantrine), Riamet (artemether, lumefantrine)
Disease: Malaria
Drug Class: Antimalarials
Related Files: Artemether – drug partner in fixed dose combinations
Date Updated: December 2022
Absorption Model |
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Volume of Distribution Details |
Note: Kp scalar and Kp adipose used |
Route of Elimination |
CYP3A4 (40%); non-specific hepatic metabolism (60%) |
Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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The V21 RES-Levonorgestrel file has been developed as a substrate of CYP3A4. The file was developed to capture the pharmacokinetics after administration of Levonorgestrel alone or in combination with Ethinyl Estradiol. A workspace and performance summary are available. Levonorgestrel is known to bind to the plasma protein Sex Hormone Binding Globulin and this has been captured in the file by utilising the other protein option in the population.
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