Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 46 Matches

Primaquine
Model Files Publication

Brand Name(s) include: Jasoprim, Malirid, Neo-Quipenyl, Pimaquin, Pmq, Primachina, Primacin, Primaquina, Primaquine, Primaquine diphosphate, Primaquine Phosphate, and Remaquin

Disease: Malaria, Plasmodium vivax, Plasmodium ovale

Drug Class: Antimalarial

Related Files: Carboxyprimaquine (metabolite)

Date Updated: March 2022

 The model at-a-glance

Absorption Model
  • First-Order

Volume of Distribution 
  • Full PBPK (Method 2)

Routes of Elimination
  • 89% MAO (entered using ‘user-UGT’ as a surrogate in the Simulator), 11% CYP2D6

Perpetrator DDI
  • CYP1A2 Inhibitor (in vitro)

Validation

  •  6 studies with single (15 to 45 mg) and multiple (15 mg QD) dosing. 100% of Cmax and AUC values within 1.5-fold.
  • No clinical DDI studies to verify contribution of metabolic routes

Limitations
  •  The active metabolites of primaquine have not characterized due to their instability. Therefore, a PBPK model for active metabolites cannot be developed in their own right.
  • Qualitative data suggests a role of P-gp, however, Jmax and Km values have not been measured.
  • There is evidence of enantiomer specific metabolism for primaquine which has not been considered in the current model.

Updates in Version 19
  • Updated in vitro protein and blood binding data and subsequent back calculation of CLint (retrograde approach)
    •  fu: 0.19 -> 0.26
    • B:P: 1 -> 0.82
  • Converted from minimal PBPK model to full PBPK model

 

Search Score: 1
Creatinine_MechKiM_V16R1_UniversityOfManchester_20210421
Model Files Publication
https://doi.org/10.1124/jpet.118.251413 Creatinine compound file with MechKiM
Search Score: 1
Sulfamethoxazole_MechKiM_V16R1_UniversityOfManchester_20210421
Model Files Publication
https://doi.org/10.1124/jpet.118.251413 Sulfamethoxazole compound file with MechKiM
Search Score: 1
Vemurafenib_V17R1_UniversityOfOklahomaHSC_20200710
Model Files Publication
Vemurafenib in Sim-Healthy Volunteers. https://jpharmsci.org/article/S0022-3549(20)30328-2/pdf
Search Score: 1

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