Quickly find freely available drug and population models in our PBPK model repository.
The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.
To contribute published user compound and/or population files, upload your files here: Upload Model Files
The Ceftazidime file is set as IV infusion of 1g over 3 minutes (0.05 h), thus the user is advised to ensure that after oral dosing an fa of 1 (CV=0%), ka of 2 h-1 (CV=30%) and a lag time of 1.5 h (30%) is used as stated in the Supplement Material Table S1 of the publication (PMID: 38675135). The Ceftazidime file has been evaluated in a Pregnant Population.
Ertugliflozin compound file, UGT1A9 and UGT2B4/7 substrate. Model developed and verified using ADME, IV PK and SD/MD clinical data. Simulated DDI with UGT inhibitor mefenamic acid. https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12581
Simcyp developed Paclitaxel compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.
Supplemental table. Ki against OAT transporters can be changed (sensitivity analysis was conducted in the referenced publication to explore "in vivo" Ki).
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