Quickly find freely available drug and population models in our PBPK model repository.
The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.>
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Brand Name(s) include: Fansidar
Disease: Malaria
Drug Class: Sulfonamide
Date Updated: March 2021
Absorption Model |
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Volume of Distribution |
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Route of Elimination |
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Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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Brand Name(s) include: Qualaquin
Disease: Malaria
Drug Class: Antimalarials
Date Updated: 2021
Absorption Model |
First-Order |
Volume of Distribution |
Minimal PBPK (Method 1) |
Route of Elimination |
CYP3A4 (fm = 0.50); renal clearance (fe = 0.1) |
Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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Simcyp developed propofol compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in the summary document.
This model is a Crohn's disease (CD) population model for adult patients, created in Simcyp version 19. Alteration of GIT parameters and other physiological parameters like albumin level incorporated based on literature available data of inactive state of CD. The demographic and formulation information are based on the published in vivo pharmacokinetics data of midazolam and budesonide in CD patients. The model details and results are published in 2022 DOI: 10.1007/s40262-022-01169-4
18 |