Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 125 Matches

Creatinine_MechKiM_V16R1_UniversityOfManchester_20210421
https://doi.org/10.1124/jpet.118.251413 Creatinine compound file with MechKiM
Sulfamethoxazole_MechKiM_V16R1_UniversityOfManchester_20210421
https://doi.org/10.1124/jpet.118.251413 Sulfamethoxazole compound file with MechKiM
Hydroxychloroquine_V18R1_PekingUniversityThirdHospital_20220209
PBPK model of Hydroxychloroquine and its metabolite of Desethyl-hydroxychloroquine. This file is a further development of the file for Hydroxychloroquine (V18R1) also available within this database: In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) - PubMed (nih.gov)
MefenamicAcid_Dapagliflozin_V15R1_Pfizer_20220726
Mefenamic acid and dapagliflozin/healthy volunteer. This workspace simulates the UGT mediated DDI after multiple dose administration of UGT inhibitor mefenamic acid. The workspace shows Dapaglifazin as substrate of UGTA9 and UGT2B7. Mefenamic Acid is used in the inhibitor position and Ki values against UGT1A9 and UGT2B7 are included in the workspace.

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