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The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.
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V18 released Simcyp files for antiretroviral drugs
Simcyp developed dolutegravir compound file. Compound summary including an outline on the current status and limitations included.
The RES-Dolutegravir model has been developed primarily as a UGT1A1 and CYP3A4 substrate, and as an inhibitor of renal MATE1 and OCT2 transporters. MATE1 and OCT2 inhibition parameters have been optimized to capture impact of dolutegravir on metformin pharmacokinetics but have not been independently verified. In vitro observed inhibition of MATE2-K by dolutegravir has not been included as the parameter could not be optimized and verified with the substrate models and clinical data available at the time of dolutegravir model development.
Brand Name(s) include: Camoquin (FDC with amodiaquine)
Disease: Malaria
Drug Class: Antimalarials
Related Drugs: DHA, Amodiaquine
Date Updated: March 2022
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Note: Kp scalar used |
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Perpetrator DDI |
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Updates in V19 |
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Brand Name(s) include: Adoxa, Doryx, Monodox, Oracea, Periostat, Vibramycin, Vibra-tabs
Disease: Malaria
Drug Class: Antibiotic
Date Updated: June 2022
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Perpetrator DDI |
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Updates in V19 |
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