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Brand Name(s) include: Daraprim
Disease: Malaria
Drug Class: Antimalarials
Date Updated: November 2021
Absorption Model |
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Volume of Distribution |
Note: Kp scalar used |
Route of Elimination |
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Perpetrator DDI |
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Validation |
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Limitations |
The current model does not mechanistically describe the absorption of pyrimethamine as the ADAM model over-predicts the extent of absorption. Although pyrimethamine is described as well absorbed in some literature, further analysis of the IV and PO data did not support this. |
Updates in V19 |
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14 |