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The RES-Chlorzoxazone file was primarily developed as an inhibitor of CYP3A4. This document provides: 1. Examples of model performance 2. A summary of the key pharmacokinetic features of Chlorzoxazone considered within the model.
Brand Name(s) include: N/A
Disease: Malaria
Drug Class: Antimalarials
Date Updated: March 2022
Related drugs: Proguanil
Absorption Model |
First-Order |
Volume of Distribution |
Full PBPK (Method 2) |
Route of Elimination |
Formed by CYP2C19, CYP3A4; unknown clearance mechanism |
Perpetrator DDI |
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Validation |
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Limitations |
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Updates in V19 |
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4 |