Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
You can also use a * character as a wildcard in the middle of a alphanumeric search term. The search term must still start with at least one character before the wildcard. E.g., Rif*in will also get you “Rifampicin” and “Rifampin” .
You can also use a * character as a wildcard at the start of a alphanumeric search term. However you must use forward slashes to delimit the search term and use a point before the wildcard. E.g., /.*picin/ will only get you “Rifampicin”.

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Found 128 Matches

Ondansetron_V14R1_AstraZeneca_20200427

Model Files Publication

Ondansetron adult compound file for paediatric prediction.

Search Score: 1

Paclitaxel_RES_V17R1_Simcyp_20180228

Model Files Publication

Simcyp developed Paclitaxel compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 1

Probenecid_V12R1_FDA_20150709

Model Files Publication

Supplemental table. Ki against OAT transporters can be changed (sensitivity analysis was conducted in the referenced publication to explore "in vivo" Ki).

Search Score: 1

Simvastatin_Acid_Lactone_RES_V23R2_Simcyp_20241122

Model Files Publication

The RES-Simvastatin lactone and RES-Simvastatin acid models within the Simcyp Compound Repository have been developed as substrates of CYP3A4, CYP2C8, BCRP (simvastatin lactone), CES1 (simvastatin lactone) and OATP1B1 (simvastatin acid). Additionally, the models account for the interconversion between the lactone and acid forms in the acidic environment of the stomach. Note: Before running a simulation, modify the population to account for gastric luminalmetabolism. To do this, follow these steps:

Go to Population > GI Tract > LuminalMetabolism> Compound > Expression
Set the relative activity to 0 for all GI segments except the stomach

This document provides:

Examples of model performance
A summary of the key pharmacokinetic features of simvastatin lactone and simvastatin acid considered within the model

Search Score: 1

Search the PBPK Model Repository

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Ondansetron_V14R1_AstraZeneca_20200427

Paclitaxel_RES_V17R1_Simcyp_20180228

Probenecid_V12R1_FDA_20150709

Simvastatin_Acid_Lactone_RES_V23R2_Simcyp_20241122

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