Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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Found 126 Matches

TB Compound File Collection

Model Files Publication

V16 TB compound files and associated manuscript, as well as South African TB population file.

Search Score: 2

Ceftibuten_V14R1_AstraZeneca_20200327

Model Files Publication

Ceftibuten for pediatric predictions.

Search Score: 2

CrohnsDiseasePopulation_V19R1_UniversityOfManchester_20230322

Model Files Publication

This model is a Crohn's disease (CD) population model for adult patients, created in Simcyp version 19. Alteration of GIT parameters and other physiological parameters like albumin level incorporated based on literature available data of inactive state of CD. The demographic and formulation information are based on the published in vivo pharmacokinetics data of midazolam and budesonide in CD patients. The model details and results are published in 2022 DOI: 10.1007/s40262-022-01169-4

Search Score: 2

Chlorpromazine

Model Files Publication

Brand Name(s) include: Thorazine, Largactil, Ormazine

Indication: Schizophrenia, manic-depression

Drug Class: Conventional anitpsychotic

Date Updated: March 2024

The model at-a-glance

Absorption Model	First-Order, fa and ka predicted by Caco-2 data
Volume of Distribution	Minimal (optimized to IV data)
Route of Elimination	fm_CYP3A4= 80, fm_CYP2D6 = 20
Perpetrator DDI	Inhibition of CYP2D6
Validation	Model performance was verified in healthy volunteers and psychiatric patients. Two clinical studies with IV administration (7 to 10 mg) and ten clinical studies with oral administration (25 to 200 mg) were used for model verification. Simulations for eight of eleven clinical studies with a reported AUC were within 2-fold of the observed value. The fm_CYP1A2was verified through simulations of chlorpromazine in smokers and non-smokers. The fm_CYP2D6was verified through simulations of chlorpromazine coadministered with and without quinidine.
Limitations	Model was developed using 10 mg IV and 100 mg PO. Use of 7-10 mg IV dosing and oral doses of 100-200 mg were verified, but predictions of oral doses <100 mg PO are overestimated. Model does not include P-gp efflux. Model is not verified for use in perpetrator DDI simulations with CYP2D6 substrates.

Search Score: 2

Search the PBPK Model Repository

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TB Compound File Collection

Ceftibuten_V14R1_AstraZeneca_20200327

CrohnsDiseasePopulation_V19R1_UniversityOfManchester_20230322

Chlorpromazine

The model at-a-glance

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