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Disease: Malaria
Drug Class: Antimalarials
Date Updated: March 2022
Related Files: Primaquine (parent)
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Absorption Model |
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Volume of Distribution |
Full PBPK (Method 2) |
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Perpetrator DDI |
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Updates in V19 |
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The V21 RES-Dasabuvir model has been developed as a substrate of CYP2C8 and CYP3A4. Compound file and performance summary are available.
Simcyp developed Docetaxel compound file. Compound summary document included. This was developed as a research file and its current status and limitations are outlined in summary document.
Simcyp developed dolutegravir compound file. Compound summary including an outline on the current status and limitations included.
The RES-Dolutegravir model has been developed primarily as a UGT1A1 and CYP3A4 substrate, and as an inhibitor of renal MATE1 and OCT2 transporters. MATE1 and OCT2 inhibition parameters have been optimized to capture impact of dolutegravir on metformin pharmacokinetics but have not been independently verified. In vitro observed inhibition of MATE2-K by dolutegravir has not been included as the parameter could not be optimized and verified with the substrate models and clinical data available at the time of dolutegravir model development.
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