Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
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Found 125 Matches

Adefovir_V15R1_USFDA_20170810

Model Files Publication

http://onlinelibrary.wiley.com/doi/10.1002/cpt.750/full Adefovir compound in healthy volunteers. Hsueh et al evaluating the effect of renal impairment on PK of OAT substrates. 30/07/2019: The Adefovir PBPK model was submitted with the setting as Hepatocyte Clearance input in the WOMC option. To allow DDI simulations the file should be set up in the Enzyme Kinetics option by moving the Hepatocyte clearance value into the Additional Clearance (Liver) subtab under the Enzyme Kinetics section.

Search Score: 2

Aripiprazole_V12R2_USFDA_20160510

Model Files Publication

Note: additional dissolution data 0.5 hr 55% not captured in the supplemental materials of the publication

Search Score: 2

V18 released Simcyp files for antiretroviral drugs

Model Files Publication

V18 released Simcyp files for antiretroviral drugs

Search Score: 2

Halofantrine_M-ADAM_V19R1_Genentech_20210323

Model Files Publication

See publication for additional details.

Search Score: 2

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Adefovir_V15R1_USFDA_20170810

Aripiprazole_V12R2_USFDA_20160510

V18 released Simcyp files for antiretroviral drugs

Halofantrine_M-ADAM_V19R1_Genentech_20210323

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